The microbiota regulates type 2 immunity through RORgt T cells
نویسندگان
چکیده
20. M. R. Bennett, J. Hasty, Nat. Rev. Genet. 10, 628–638 (2009). 21. T. Y. Tsai et al., Science 321, 126–129 (2008). 22. J. K. Kim, D. B. Forger, Mol. Syst. Biol. 8, 630 (2012). 23. B. Novák, J. J. Tyson, Nat. Rev. Mol. Cell Biol. 9, 981–991 (2008). 24. E. L. O’Brien, E. Van Itallie, M. R. Bennett, Math. Biosci. 236, 1–15 (2012). 25. F. Naqib et al., Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 85, 046210 (2012). 26. W. H. Mather, N. A. Cookson, J. Hasty, L. S. Tsimring, R. J. Williams, Biophys. J. 99, 3172–3181 (2010). 27. A. Prindle et al., Nature 508, 387–391 (2014). 28. H. Cho et al., Nature 485, 123–127 (2012). 29. W. Mather, M. R. Bennett, J. Hasty, L. S. Tsimring, Phys. Rev. Lett. 102, 068105 (2009).
منابع مشابه
MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.
Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that microbiota-induced T(regs) express the nuclear...
متن کاملAll-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway
متن کامل
Gastrointestinal Inflammation and Repair: Role of Microbiome, Infection, and Nutrition
Gastrointestinal inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Symbiotic microbiome in digestive tract is considered to protect gut by removing harmful stimuli and to enhance healing process. Alteration or absence of microbiome can lead to exacerbated type 2 immunity and allergic/infectious and inflammato...
متن کاملType 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis
BACKGROUND Dynamic interactions between the host and gastrointestinal microbiota play an important role for local and systemic immune homeostasis. Helminthic parasites modulate the host immune response, resulting in protection against autoimmune disease but also increased susceptibility to pathogen infection. The underlying mechanisms remain largely unknown. RESULTS We showed that the type 2 ...
متن کاملMicrobiota regulates immune defense against respiratory tract influenza A virus infection.
Although commensal bacteria are crucial in maintaining immune homeostasis of the intestine, the role of commensal bacteria in immune responses at other mucosal surfaces remains less clear. Here, we show that commensal microbiota composition critically regulates the generation of virus-specific CD4 and CD8 T cells and antibody responses following respiratory influenza virus infection. By using v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015